Tolerance and autoimmunity: Entwined pathways lead to immunological tolerance
نویسندگان
چکیده
منابع مشابه
Immunological Tolerance
Although most mouse strain combinations succumb to a lethal wasting disease when parabiosed across a strong histocompatibility (H-2) barrier, a high proportion of DBA mice parabiosed to DBA/C3H F(1) hybrids survive and appear healthy. DBA mice accept C3H skin grafts following parabiosis, and may therefore be considered operationally tolerant of C3H antigens. Nonetheless, spleen cells from long-...
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Grand ChallenGes The question of self–non-self discrimination, and thereby immunological tolerance, is as old as our appreciation of the receptor-diversity in the immune system. Initially negative selection of self-reactive lymphocytes by clonal deletion in primary lymphoid organs, enhanced by promiscuous expression of ectopic antigens in these organs, attracted attention. It became clear, howe...
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Treatment of mice with a nonimmunogenic preparation of free reactive hapten, trinitrobenzene sulfonic acid (TNBS), leads to the induction of a state of tolerance to the hapten, 2,4,6-trinitrophenyl (TNP). This is determined by the lack of response to the haptenic moiety in an immunogenic hapten-carrier conjugate (TNP-SRBC) as assayed both by serum antibody titrations and the hemolytic plaque as...
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This book is part of a series called Fundamental and Clinical Aspects of Internal Medicine, a series of volumes for a postgraduate course. Short chapters cover the subjects of cytogenetics, mendelian genetics, genetic markers, multifactorial inheritance, biochemical genetics, genetics of cancer, and treatment of genetic disease. It attempts to be a fairly comprehensive resource for clinicians w...
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ژورنال
عنوان ژورنال: Immunology & Cell Biology
سال: 2007
ISSN: 0818-9641,1440-1711
DOI: 10.1038/sj.icb.7100059